Thyroid Hormone Changes After Sleeve Gastrectomy With and Without Antral Preservation.

Area of Science:

• Bariatric Surgery
• Endocrinology
• Metabolic Surgery

Background:

• Bariatric surgery's impact on thyroid hormones is inconsistent.
• Laparoscopic sleeve gastrectomy (LSG) is a common bariatric procedure.
• Thyroid hormone regulation is crucial in metabolic health.

Purpose of the Study:

• To evaluate thyroid hormone (TSH, FT3, FT4) changes after LSG.
• To compare LSG with antral resection (AR) versus antral preservation (AP).
• To assess the influence of weight loss on thyroid function post-LSG.

Main Methods:

• Prospective study of euthyroid obese patients undergoing LSG.
• Thyroid hormones measured preoperatively, at 1 month, and 1 year post-LSG.
• Comparison of outcomes between AR (n=58) and AP (n=48) groups.

Main Results:

• Significant decrease in FT3 and TSH levels post-LSG; FT4 levels unchanged.
• AR group showed significantly higher weight loss (BMI, %EBMIL, %TWL) than AP group.
• Greater reduction in FT3 levels observed in the AR group compared to the AP group.

Conclusions:

• LSG effectively reduces TSH and FT3, while FT4 remains stable.
• LSG with AR results in superior short-term weight loss and greater FT3 reduction.
• Antral resection may play a role in modulating thyroid hormone levels post-LSG.