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Current Overview on Hypercoagulability in COVID-19

Namrata Singhania1, Saurabh Bansal2, Divya P Nimmatoori3

  • 1Department of Hospital Medicine, Mount Carmel East Hospital, 6001 E Broad Street, Columbus, OH, 43213, USA. namrat09@gmail.com.

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
|August 5, 2020
PubMed

Insights

The coronavirus disease 2019 (COVID-19) pandemic is linked to COVID-19-associated coagulopathy (CAC), causing blood clots. Understanding CAC pathogenesis and clinical features is crucial for effective management strategies.

Area of Science:

  • Internal Medicine
  • Hematology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents unique pathologies including coagulopathy.
  • COVID-19-associated coagulopathy (CAC) leads to thromboembolic complications, particularly in severe cases.

Purpose of the Study:

  • To comprehensively review the current literature on COVID-19-associated coagulopathy.
  • To highlight the pathogenesis, clinical features, and management of CAC.

Main Methods:

  • Literature review of existing studies on COVID-19-associated coagulopathy.
  • Synthesis of information regarding the mechanisms, presentation, and treatment of CAC.

Main Results:

  • Pathogenesis likely involves endothelial injury, immobilization, and increased prothrombotic factors.
  • Limited treatment data exists, but prophylactic anticoagulation is recommended for hospitalized patients.
  • Review covers pathogenesis, clinical features, and management strategies for CAC.

Conclusions:

  • Effective management of COVID-19-associated coagulopathy is urgently needed.
  • Further research is required to establish definitive treatment protocols for CAC.

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