Chitosan-stabilized selenium nanoparticles attenuate acrylamide-induced brain injury in rats

Acrylamide (ACR) is produced during food processing and has been shown to cause health problems. Selenium, especially in its nanoscale, is an important trace element in human nutrition. Chitosan-stabilized selenium nanoparticles (Ch-SeNPs) stability and its protective potential against ACR-induced injury in rats were evaluated. Ch-SeNPs displayed high radical-scavenging activity and reducing power that were not significantly changed for 60 days at 4°C. The transmission electron microscopy images and dynamic light scattering results demonstrated high stability of Ch-SeNPs during storage. ACR (20 mg kg^-1 day^-1) led to elevate the level of malondialdehyde, dopamine and noradrenaline in blood serum, and cerebral cortex. Ch-SeNPs (0.2 mg kg^-1 day^-1) displayed more protection against ACR-induced damages comparing to Na₂SeO₃. More than 90% of the glutathione pool in the brain tissue was in reduced form. Correlation coefficient analysis demonstrated the attenuating effect of Ch-SeNPs against ACR-induced brain-injury and hormone imbalance. Administrating Ch-SeNPs 15 days before ACR-treatment is required for obtaining the best protection. PRACTICAL APPLICATIONS: Ch-SeNPs used in the present study characterized by its high storage stability for two months without losing its antioxidant potential. After conducting toxicity tests, it is suggested to supplement some foods with Ch-SeNPs because of its high antioxidant potential and significant protection ability against the oxidative stress damages in living organisms. These advantages may nominate the Ch-SeNPs for several industrial applications in the field of food processing and protection.