Cross-reactive antigens and HLA matching
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Updated: Nov 5, 2026

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
1Department of Pathology, University of Florida College of Medicine, Gainesville 32610.
Abstract:
Anti-HLA-A2 and anti-B17 reactivity of 87 broadly reactive sera was studied by inhibition of monoclonal Ab binding. These Abs were detected as often in patients bearing Ags cross-reactive with A2 or B17 as in those not bearing such Ags. These results indicate that predictions of negative cross-matches based on Ag cross-reactivity or reactivity against public epitopes will not be accurate in a high proportion of cases.
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