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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Recent Advances in Treatment of Lung Cancer: Nanoparticle-based Drug and siRNA Delivery Systems
Ayse Gencer1, Ceren Duraloglu1, Sena Ozbay2
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Abstract:
Lung cancer is the second most diagnosed cancer in both men and women worldwide. Considering the high mortality rate of lung cancer and inadequacy of conventional treatment methods such as surgical resection, chemotherapy and radiotherapy; new treatment strategies are an emerging area of interest. Nanoparticle-based drug and small interfering RNA delivery systems such as lipid, polymeric, inorganic, micellar and dendrimer nanoparticles are designed to enhance the bioavailability, stability and retention of anti-cancer drugs in the targeted regions of the lung. These nanoparticle-based delivery systems increase the active ingredient half-life and targeting efficiency while reducing the required dose of the drug. Hence, they have many advantages such as higher therapeutic efficacy and reducedside effects and adverse events. Combinations of active ingredients, anti-cancer agents and small interfering RNA can be formulated into nanoparticle-based delivery systems that can be administered by various routes including inhalation and intravenous. In this review, the development of lipidic and polymeric nanoparticle-based drug and small interfering RNA delivery systems used in the treatment of lung cancer is discussed.
Insights
Novel nanoparticle delivery systems offer enhanced lung cancer treatment by improving drug efficacy and reducing side effects. These systems utilize lipid and polymeric nanoparticles for targeted delivery of anti-cancer agents and small interfering RNA.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Lung cancer is a leading cause of cancer-related mortality worldwide.
- Conventional treatments like surgery, chemotherapy, and radiotherapy have limitations.
- There is a critical need for innovative therapeutic strategies to improve patient outcomes.
Purpose of the Study:
- To review the development of nanoparticle-based delivery systems for lung cancer treatment.
- To explore the application of lipidic and polymeric nanoparticles for drug and small interfering RNA delivery.
- To highlight the advantages of these advanced systems in enhancing therapeutic efficacy and reducing adverse events.
Main Methods:
- Review of current literature on nanoparticle-based drug and small interfering RNA delivery systems.
- Focus on lipidic and polymeric nanoparticle formulations.
- Discussion of administration routes, including inhalation and intravenous delivery.
Main Results:
- Nanoparticle systems significantly enhance the bioavailability, stability, and retention of anti-cancer agents in lung tissues.
- These systems improve the half-life and targeting efficiency of active ingredients, allowing for reduced drug dosage.
- Nanoparticle formulations demonstrate potential for higher therapeutic efficacy with fewer side effects compared to conventional methods.
Conclusions:
- Lipidic and polymeric nanoparticle-based delivery systems represent a promising advancement in lung cancer therapy.
- These systems offer a viable strategy to overcome the limitations of traditional treatments.
- Further research and development in this area could lead to improved clinical outcomes for lung cancer patients.
