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The Relationship between HDAC3 and Malignant Tumors: A Mini Review
Lou Tong1, Haotian Liang2, Huiyu Zhuang2
1Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Critical Reviews in Eukaryotic Gene Expression
|August 5, 2020
Summary
Histone deacetylases 3 (HDAC3) is crucial in cell functions and cancer progression. This review explores HDAC3
Area of Science:
- Molecular Biology
- Oncology
- Biochemistry
Background:
- Histone deacetylases 3 (HDAC3) is part of the histone deacetylase family, involved in vital cellular processes.
- These processes include signal transduction, cell cycle regulation, proliferation, apoptosis, and cardiac development.
Purpose of the Study:
- To review the fundamental characteristics of HDAC3.
- To elucidate the significant role of HDAC3 in the development and progression of malignant tumors.
Main Methods:
- Literature review of existing research on HDAC3.
- Analysis of studies linking HDAC3 to cancer hallmarks.
Main Results:
- HDAC3 is implicated in key aspects of tumor progression.
- These include proliferation, apoptosis, metastasis, angiogenesis, and drug resistance.
Conclusions:
- HDAC3 is a critical factor in malignant tumor progression.
- Understanding HDAC3's role may offer therapeutic targets for cancer treatment.
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