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Updated: Dec 13, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Metal catalyst-free photo-induced alkyl C-O bond borylation
Guobin Ma1, Changzhou Chen1, Sangita Talukdar1
1Center for Supramolecular Chemistry and Catalysis, Department of Chemistry and Department of Physics and Institute for the Conservation of Cultural Heritage, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China. chlei@shu.edu.cn Hegui_gong@shu.edu.cn.
Abstract:
Metal catalyst free, blue visible light-induced C-O bond borylation of unactivated tertiary alkyl methyl oxalates has been developed to furnish tertiary alkyl boronates. From the secondary alcohols activated with imidazolylthionyl, moderate yields of boronates were attained under standard photo-induced conditions. Preliminary mechanistic studies confirmed the involvement of a (DMF)2-B2cat2 adduct that weakly absorbs light at 437 nm so as to initiate a Bcat radical. A radical-chain process is proposed wherein the alkyl radical is engaged.
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