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Updated: Dec 13, 2025
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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
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[Lactate in emergency medicine].
Andre Kramer1, Sascha Al Agha2, Lennert Böhm2
1Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland.
Der Anaesthesist
|August 5, 2020
Summary
Lactate, a key energy carrier and end-product of anaerobic glycolysis, can indicate serious conditions when levels are high (hyperlactatemia). Monitoring lactate levels is crucial for assessing patient status and guiding emergency medical treatment.
Area of Science:
- Biochemistry
- Metabolic processes
- Energy metabolism
Background:
- Lactate is the end-product of anaerobic glycolysis and a vital energy carrier.
- It serves as a substrate for gluconeogenesis and oxidation.
- Hyperlactatemia, or elevated blood lactate, signals numerous acute medical emergencies.
Purpose of the Study:
- To highlight the significance of lactate in metabolic processes.
- To underscore the diagnostic and prognostic value of hyperlactatemia in acute conditions.
- To emphasize the importance of monitoring lactate dynamics in emergency medicine.
Main Methods:
- Review of metabolic pathways involving lactate.
- Analysis of clinical conditions associated with hyperlactatemia.
- Discussion of the role of repetitive lactate measurements in patient management.
Main Results:
- Hyperlactatemia is linked to various critical events like shock, sepsis, and cardiac arrest.
- Elevated lactate levels are associated with increased patient mortality.
- Dynamic monitoring of blood lactate aids in assessing patient condition and treatment efficacy.
Conclusions:
- Identifying the cause of hyperlactatemia is critical in emergency medicine.
- Effective causal treatment and monitoring of lactate levels are essential for improving patient outcomes.
- Repetitive lactate measurements are integral to modern treatment algorithms for acute conditions.
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