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Updated: Dec 13, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Preventing Perinatal Depression Now: A Call to Action.
Tamara E Lewis Johnson1, Camille A Clare2, Jennifer E Johnson3
1National Institutes of Health, National Institute of Mental Health, Office of Disparities Research and Workforce Diversity, Rockville, Maryland, USA.
Perinatal depression (PD) affects many pregnant and postpartum individuals, with high undiagnosed rates. Research highlights key strategies for screening, prevention, and understanding PD within its psychosocial context.
Area of Science:
- Perinatal mental health
- Public health interventions
- Maternal health
Background:
- Perinatal depression (PD) is a common complication affecting 11.5% of pregnant and postpartum individuals annually in the US.
- A significant gap exists in PD diagnosis, with up to 51% of cases remaining undiagnosed.
- While screening tools are available, there's no consensus on the most accurate or on universal screening policies.
Purpose of the Study:
- To address the critical need for improved perinatal depression (PD) screening and prevention strategies.
- To highlight evidence-based programs recommended by the USPSTF for PD prevention.
- To emphasize the importance of community-based support for diverse populations.
Main Methods:
- Review of existing screening tools and prevention programs for perinatal depression (PD).
- Analysis of the US Preventive Services Task Force (USPSTF) 2019 recommendation for PD prevention.
- Consideration of community-based advocacy efforts for diverse pregnant and postpartum women.
Main Results:
- The USPSTF recommends PD prevention programs, citing the ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns) and Mothers and Babies programs.
- Effective interventions like cognitive behavioral therapy are available for PD prevention.
- Grassroots efforts support diverse pregnant and postpartum women.
Conclusions:
- Standardizing multicultural PD screening tools and establishing evidence-based screening timepoints are crucial.
- An evidence-based definition of PD is needed to accurately reflect its prevalence and incidence.
- Integrating the psychosocial context of mental health into routine clinical care for pregnant and postpartum women is essential for improving understanding and outcomes.
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