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Updated: Dec 13, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Preventing Perinatal Depression Now: A Call to Action
Tamara E Lewis Johnson1, Camille A Clare2, Jennifer E Johnson3
1National Institutes of Health, National Institute of Mental Health, Office of Disparities Research and Workforce Diversity, Rockville, Maryland, USA.
Insights
Perinatal depression (PD) affects many pregnant and postpartum individuals, with high undiagnosed rates. Research highlights key strategies for screening, prevention, and understanding PD within its psychosocial context.
Area of Science:
- Perinatal mental health
- Public health interventions
- Maternal health
Background:
- Perinatal depression (PD) is a common complication affecting 11.5% of pregnant and postpartum individuals annually in the US.
- A significant gap exists in PD diagnosis, with up to 51% of cases remaining undiagnosed.
- While screening tools are available, there's no consensus on the most accurate or on universal screening policies.
Purpose of the Study:
- To address the critical need for improved perinatal depression (PD) screening and prevention strategies.
- To highlight evidence-based programs recommended by the USPSTF for PD prevention.
- To emphasize the importance of community-based support for diverse populations.
Main Methods:
- Review of existing screening tools and prevention programs for perinatal depression (PD).
- Analysis of the US Preventive Services Task Force (USPSTF) 2019 recommendation for PD prevention.
- Consideration of community-based advocacy efforts for diverse pregnant and postpartum women.
Main Results:
- The USPSTF recommends PD prevention programs, citing the ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns) and Mothers and Babies programs.
- Effective interventions like cognitive behavioral therapy are available for PD prevention.
- Grassroots efforts support diverse pregnant and postpartum women.
Conclusions:
- Standardizing multicultural PD screening tools and establishing evidence-based screening timepoints are crucial.
- An evidence-based definition of PD is needed to accurately reflect its prevalence and incidence.
- Integrating the psychosocial context of mental health into routine clinical care for pregnant and postpartum women is essential for improving understanding and outcomes.
Abstract:
In the United States, perinatal depression (PD) affects an estimated 11.5% of pregnant and postpartum individuals annually and is one of the most common complications of pregnancy and the postpartum period. Alarmingly, up to 51% of people with PD are undiagnosed. Despite the availability of tools to screen for PD, there is no consensus on which tool is most accurate, nor is there a universal policy on when and how to best screen patients with PD. Screening to identify PD is essential, but prevention of depression is even more critical, yet traditionally not well addressed until recently with the US Preventive Services Task Force (USPSTF) recommendation in 2019. When the USPSTF recommended implementing programs to prevent PD in at-risk individuals, the recommendation cited two evidence-based PD prevention programs by name. One of these, ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns), is a four-session class taught in prenatal settings. The second program mentioned is the Mothers and Babies program, which has been shown to be effective in using a cognitive behavioral therapy approach to prevent PD. Although scientists develop effective mental health interventions to prevent PD, community-based advocacy groups are engaged in grassroots efforts to provide support and encouragement to racially and ethnically diverse pregnant and postpartum women. To increase the number of pregnant and postpartum women who are screened and supported so that they do not develop PD, research supports three key strategies: (1) Establish a standard combination of multicultural PD screening tools with evidence-based timepoints for screening administration. (2) Introduce an evidence-based definition of PD that accurately captures the prevalence and incidence of this mental health condition. (3) Improve our understanding of PD by incorporating the psychosocial context in which mental health complications occur into routine clinical practice for pregnant and postpartum women.
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