Related Experiment Video

Updated: Dec 13, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.6K

A review of the main histopathological findings in coronavirus disease 2019

Walter O Vasquez-Bonilla1, Roberto Orozco2, Víctor Argueta2

  • 1Department of Pathology, Hospital General San Juan de Dios, Guatemala City (Ciudad de Guatemala), 01001, Guatemala; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Risaralda, 660003, Colombia.

Human Pathology
|August 5, 2020
PubMed

Insights

This study reviews the histopathologic findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Understanding these histologic details is crucial for comprehending COVID-19

Area of Science:

  • Pathology
  • Virology
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
  • SARS-CoV-2 infection affects multiple organs, including lungs, heart, kidneys, and the central nervous system.

Purpose of the Study:

  • To systematically analyze and review histopathologic findings in COVID-19.
  • To enhance understanding of COVID-19 pathophysiology and its public health impact.

Main Methods:

  • Systematic meta-analysis of histopathologic observations.
  • Review of reported findings on SARS-CoV-2 infection.

Main Results:

  • Detailed histopathologic findings in various organs: lungs (diffuse alveolar damage, pneumonia), heart (myocarditis), kidneys (acute tubular injury), CNS (thrombi, infarction), lymph nodes (hemophagocytosis), bone marrow (hemophagocytosis), and vasculature (thrombosis).

Conclusions:

  • Histopathologic analysis is essential for understanding the diverse pathology of COVID-19.
  • Comprehensive review of histologic data aids in grasping disease mechanisms and outcomes.

Keywords:
AutopsyCOVID-19HistopathologyPathologySARS-CoV-2

More Related Videos

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

2.5K
Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

2.0K

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K
Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
3.7K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
2.2K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.0K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
157