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Updated: Dec 13, 2025

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Nutrition and Psoriasis.

Naoko Kanda1, Toshihiko Hoashi2, Hidehisa Saeki2

  • 1Department of Dermatology, Nippon Medical School, Chiba Hokusoh Hospital, Inzai, Chiba 270-1694, Japan.

International Journal of Molecular Sciences
|August 6, 2020
PubMed
Summary

Nutrition significantly impacts psoriasis, a chronic inflammatory skin condition. Specific nutrients can worsen or improve psoriasis by modulating inflammatory pathways and gut health.

Keywords:
dysbiosisinterleukin-17n-3 polyunsaturated fatty acidnutritionpsoriasisregulatory T cellsaturated fatty acidshort chain fatty acidvitamin D

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Area of Science:

  • Dermatology and Nutritional Science

Background:

  • Psoriasis is a chronic inflammatory skin disease linked to specific immune pathways and comorbidities like obesity and diabetes.
  • Patients often exhibit dietary patterns high in fat and low in fish and fiber, potentially influencing disease severity.
  • Gut dysbiosis and nutrient deficiencies (e.g., vitamin D, selenium) are common in psoriasis patients.

Purpose of the Study:

  • To review the current understanding of how nutrients and food affect psoriasis development and progression.
  • To explore the role of nutrition in managing psoriasis and its associated health conditions.
  • To update information on the stimulatory and regulatory effects of nutrients on psoriasis.

Main Methods:

  • Literature review and synthesis of existing research on nutrition and psoriasis.
  • Analysis of mechanisms by which nutrients influence inflammatory pathways (e.g., TNF-α/IL-23/IL-17 axis, NLRP3 inflammasome).
  • Examination of the impact of dietary components on gut microbiota and immune cell function.

Main Results:

  • Certain dietary components (saturated fats, simple sugars, alcohol) can exacerbate psoriasis by activating inflammatory pathways and gut dysbiosis.
  • Other nutrients (n-3 PUFAs, vitamin D, fiber, probiotics) may ameliorate psoriasis by suppressing inflammation and modulating immune responses.
  • Psoriasis is associated with gut microbiota imbalances and deficiencies in vitamin D and selenium.

Conclusions:

  • Dietary habits play a crucial role in the pathogenesis and management of psoriasis.
  • Nutritional interventions targeting specific nutrients and food components show potential for alleviating psoriasis symptoms and comorbidities.
  • Further research into personalized nutritional strategies is warranted for effective psoriasis management.