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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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Dengue: A Minireview.

Harapan Harapan1,2,3,4, Alice Michie4, R Tedjo Sasmono5

  • 1Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh 23111, Indonesia.

Viruses
|August 6, 2020
PubMed
Summary

Dengue virus (DENV) infection poses a significant global health threat, with incidence rising dramatically. This review covers DENV biology, epidemiology, and control strategies, including vaccines.

Keywords:
denguediagnosisdisease controlepidemiologypathogenesistreatment

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Area of Science:

  • * Virology and Epidemiology
  • * Public Health and Tropical Medicine

Background:

  • * Dengue virus (DENV), with four serotypes (DENV-1 to DENV-4), is a major mosquito-borne public health concern.
  • * Global incidence has surged 30-fold in 50 years, with over half the world's population at risk.
  • * The disease causes significant morbidity, mortality, and economic burden, especially in developing nations.

Purpose of the Study:

  • * To provide a comprehensive review of Dengue virus (DENV) biology and epidemiology.
  • * To summarize current knowledge on DENV transmission dynamics, immune responses, and pathogenesis.
  • * To present updated information on diagnostic methods, treatments, vector control, and vaccine development.

Main Methods:

  • * Literature review of scientific publications on Dengue virus.
  • * Synthesis of data on DENV serotypes, genotypes, and transmission patterns.
  • * Compilation of information on clinical aspects, diagnostics, and interventions.

Main Results:

  • * DENV remains a significant global health challenge with increasing incidence and geographic spread.
  • * Understanding of DENV's complex biology, immune interactions, and pathogenesis continues to evolve.
  • * Advancements in diagnostics, treatments, vector control, and vaccine development are ongoing.

Conclusions:

  • * Dengue virus (DENV) presents a growing global health threat requiring multifaceted control strategies.
  • * Continued research into DENV biology, pathogenesis, and immunology is crucial for effective interventions.
  • * Integrated approaches combining diagnostics, therapeutics, vector control, and vaccination are essential for managing Dengue.