Related Experiment Video

Updated: Dec 13, 2025

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.0K

Protective Immunity Induced by Virus-Like Particle Containing Merozoite Surface Protein 9 of Plasmodium berghei

Su-Hwa Lee1, Hae-Ji Kang1, Ki-Back Chu1

  • 1Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.

Vaccines
|August 6, 2020
PubMed

Insights

Virus-like particles (VLPs) targeting malaria merozoite surface protein 9 (MSP-9) induced immune responses in mice. This malaria vaccine candidate prolonged survival against Plasmodium berghei infection.

Area of Science:

  • Immunology
  • Vaccinology
  • Parasitology

Background:

  • Merozoite surface protein 9 (MSP-9) from Plasmodium is a potential malaria vaccine target.
  • Its role in erythrocyte invasion makes it crucial for parasite lifecycle.

Purpose of the Study:

  • To develop and evaluate virus-like particles (VLPs) targeting Plasmodium berghei MSP-9.
  • To assess the protective efficacy of MSP-9 VLPs in a murine malaria model.

Main Methods:

  • Generation of VLPs displaying P. berghei MSP-9.
  • Immunization of mice with MSP-9 VLPs.
  • Assessment of humoral and cellular immune responses (IgG, CD4+, CD8+ T cells).
  • Evaluation of protection against lethal P. berghei challenge.

Main Results:

  • VLP vaccination elicited P. berghei-specific IgG antibodies and T cell responses.
  • Vaccinated mice showed increased CD4+ and CD8+ effector memory T cells and memory B cells.
  • MSP-9 VLP immunization reduced pro-inflammatory cytokines (IFN-γ, IL-6), parasite replication, and prolonged survival.

Conclusions:

  • MSP-9 VLPs effectively induced immune responses in mice.
  • This malaria vaccine candidate demonstrated protection against P. berghei infection.
  • MSP-9 VLPs show promise as a potential malaria vaccine.
Keywords:
Plasmodium bergheimerozoite surface protein 9vaccinevirus-like particle

More Related Videos

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.5K
In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes08:20

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

2.5K

Related Concept Videos

Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
36.5K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.5K