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Updated: Dec 13, 2025

Retroviral Scanning: Mapping MLV Integration Sites to Define Cell-specific Regulatory Regions
Published on: May 28, 2017
Insights into Sensing of Murine Retroviruses
Eileen A Moran1, Susan R Ross1
1Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, 835 S. Wolcott Avenue, Chicago, IL 60612, USA.
Abstract:
Retroviruses are major causes of disease in animals and human. Better understanding of the initial host immune response to these viruses could provide insight into how to limit infection. Mouse retroviruses that are endemic in their hosts provide an important genetic tool to dissect the different arms of the innate immune system that recognize retroviruses as foreign. Here, we review what is known about the major branches of the innate immune system that respond to mouse retrovirus infection, Toll-like receptors and nucleic acid sensors, and discuss the importance of these responses in activating adaptive immunity and controlling infection.
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