Related Experiment Video
Updated: Dec 13, 2025
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
The Role of Pre-Clinical 3-Dimensional Models of Osteosarcoma
Hannah L Smith1,2, Stephen A Beers1, Juliet C Gray1
1Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton, Faculty of Medicine, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.
Abstract:
Treatment for osteosarcoma (OS) has been largely unchanged for several decades, with typical therapies being a mixture of chemotherapy and surgery. Although therapeutic targets and products against cancer are being continually developed, only a limited number have proved therapeutically active in OS. Thus, the understanding of the OS microenvironment and its interactions are becoming more important in developing new therapies. Three-dimensional (3D) models are important tools in increasing our understanding of complex mechanisms and interactions, such as in OS. In this review, in vivo animal models, in vitro 3D models and in ovo chorioallantoic membrane (CAM) models, are evaluated and discussed as to their contribution in understanding the progressive nature of OS, and cancer research. We aim to provide insight and prospective future directions into the potential translation of 3D models in OS.
Insights
Osteosarcoma (OS) treatments need innovation. This review evaluates three-dimensional (3D) models, including animal, in vitro, and in ovo chorioallantoic membrane (CAM) models, for advancing OS research and therapy development.
Area of Science:
- Oncology
- Biomedical Engineering
- Cancer Research
Background:
- Osteosarcoma (OS) treatment has seen limited advancement for decades, primarily relying on chemotherapy and surgery.
- Developing novel therapeutic targets for OS remains challenging, highlighting the need for better understanding of the tumor microenvironment.
Purpose of the Study:
- To review and evaluate the utility of various three-dimensional (3D) models in understanding osteosarcoma.
- To explore the potential translation of these 3D models for future OS therapies.
Main Methods:
- Evaluation of in vivo animal models for osteosarcoma research.
- Assessment of in vitro 3D cell culture models for OS studies.
- Discussion of in ovo chorioallantoic membrane (CAM) models in cancer research.
Main Results:
- Three-dimensional models offer enhanced insights into complex mechanisms and interactions within the OS microenvironment.
- Different 3D models provide unique advantages for studying tumor progression and evaluating therapeutic responses.
Conclusions:
- Advanced 3D models are crucial for improving our comprehension of osteosarcoma.
- These models hold significant promise for accelerating the development of effective new therapies for OS patients.
