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Triglycerides to High-Density Lipoprotein Cholesterol Ratio Predicts Chronic Renal Disease in Patients without
Vaia D Raikou1, Despina Kyriaki2, Sotiris Gavriil3
1Department of Nephrology, Doctors' Hospital, 26 Kefallinias, Athens 11257, Greece.
Insights
The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio may predict chronic kidney disease (CKD) progression in non-diabetic individuals. A higher TG/HDL-C ratio is linked to reduced kidney function and increased albuminuria, suggesting its role in arterial stiffening.
Area of Science:
- Cardiovascular Health
- Nephrology
- Metabolic Syndrome
Background:
- The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio is a recognized marker for cardiovascular risk.
- Its potential role in predicting atherosclerosis in chronic kidney disease (CKD) warrants further investigation.
Purpose of the Study:
- To evaluate the TG/HDL-C ratio's predictive value for CKD in non-diabetic individuals.
- To assess the association between the TG/HDL-C ratio and kidney function markers like estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR).
Main Methods:
- 183 non-diabetic participants were classified based on eGFR and UACR using Kidney Disease Improving Global Outcomes criteria.
- Estimated pulse wave velocity (ePWV) was calculated, and the TG/HDL-C ratio was determined.
- Statistical analyses, including chi-squared tests and adjusted models, were employed to identify predictors.
Main Results:
- The TG/HDL-C ratio showed an inverse association with eGFR and a positive association with UACR and ePWV.
- A high TG/HDL-C ratio was significantly associated with lower eGFR, higher UACR, and hypertension.
- The TG/HDL-C ratio independently predicted low eGFR and elevated UACR in older hypertensive individuals.
Conclusions:
- The TG/HDL-C ratio serves as a potential predictor for reduced eGFR and albuminuria in non-diabetic patients.
- Arterial stiffening is implicated as a key pathophysiological mechanism linking the TG/HDL-C ratio to CKD progression.
Background:
The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been included in the potential indices for atherosclerosis in chronic kidney disease (CKD). In this study, we addressed the role of the TG/HDL-C ratio on CKD prediction defined by both classified estimated glomerular filtration rate (eGFR) and classified urinary albumin-to-creatinine ratio (UACR) in non-diabetic participants.
Methods:
One hundred and eighty-three subjects with a mean age 67.3 ± 15.6 years old were included. Our participants were classified in both eGFR and UACR categories according to the Kidney Disease Improving Global Outcomes 2012 criteria. Estimated pulse wave velocity (ePWV) was calculated using an equation from age and mean blood pressure. The TG/HDL-C ratio was calculated. X2 tests and adjusted models were applied using confounders.
Results:
The TG/HDL-C ratio was inversely associated with eGFR and positively with both UACR and ePWV. We divided our patients in two groups according to the found ROC curve of the TG/HDL-C ratio cut-off point, either with an eGFR of less or more than 60 mL/min/1.73 m2. X2 tests showed significant association between the high TG/HDL-C ratio and classified eGFR, and classified UACR and hypertension (x2 = 24.5, p = 0.001, x2 = 12.5, p = 0.002 and x2 = 12.6, p = 0.001, respectively). The adjusted model showed the high TG/HDL-C ratio to be an independent predictor for both a low eGFR and UACR (OR = 1.5, 1.2-1.9 and OR = 1.22, 1.02-1.47, respectively) in combination with old age and hypertension.
Conclusion:
The TG/HDL-C ratio was revealed to be a potential predictor for both a low eGFR and micro/macroalbuminuria in non-diabetic patients. The arterial stiffening was included in the main underlying pathophysiological mechanisms.
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