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"APS pregnancy - The offspring".

Viktoria Bitsadze1, Cecilia Nalli2, Jamilya Khizroeva1

  • 1Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

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Summary
This summary is machine-generated.

Antiphospholipid antibody syndrome (APS) in pregnant women can affect offspring, with potential risks including neonatal thrombosis and neurological issues. Long-term follow-up is crucial for monitoring developmental outcomes in these children.

Keywords:
Antiphospholipid syndromechildren outcomeneonatal thrombosis

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatology
  • Immunology

Background:

  • Antiphospholipid antibody syndrome (APS) is an autoimmune condition impacting women of childbearing age.
  • Pregnancy management in APS has improved, but prematurity remains a concern due to placental effects of antiphospholipid antibodies (aPL).
  • Maternal IgG aPL may cross the placenta, potentially affecting fetal brain development, though this is debated.

Observation:

  • Neonatal thrombosis and minor neurological disorders have been reported in offspring of APS patients.
  • Some neonatal thrombosis cases occurred without maternal aPL positivity, suggesting possible fetal/neonatal aPL synthesis.
  • A case of neonatal catastrophic antiphospholipid syndrome (CAPS) was described.

Findings:

  • Offspring of APS patients are generally healthy.
  • However, risks of neonatal thrombosis and subtle neurological impairments exist.

Implications:

  • Further research is needed due to limited data on aPL effects on offspring.
  • Clinical follow-up of children born to mothers with APS is essential.
  • Monitoring for neonatal thrombosis and long-term learning or behavioral issues is recommended.