Related Experiment Video
Updated: Dec 13, 2025

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
Published on: May 19, 2020
Routine Childhood Vaccines Given From 1 through 18 Years of Age
1Department of Pediatric and Adolescent Medicine, Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
Insights
Childhood vaccination schedules extend beyond the first year, with key vaccines recommended for infectious disease prevention. These include measles, mumps, rubella, varicella, hepatitis A, and others, ensuring long-term protection.
Area of Science:
- Pediatrics
- Immunology
- Public Health
Background:
- Childhood vaccination is crucial for preventing infectious diseases.
- The US Advisory Committee on Immunization Practices provides regular vaccine recommendations.
- Vaccines protect against immediate risks and offer long-term immunity.
Purpose of the Study:
- To outline the recommended vaccination schedule for children after their first year of life.
- To detail specific vaccines and their timing for optimal protection.
- To emphasize the importance of adhering to immunization schedules for public health.
Main Methods:
- Review of recommendations from the US Advisory Committee on Immunization Practices.
- Identification of vaccine series and individual doses due at specific age intervals.
- Categorization of vaccines based on age and disease prevention.
Main Results:
- Key vaccines recommended between 12-15 months include measles-mumps-rubella (MMR) and varicella.
- Infants require hepatitis A, Haemophilus influenzae type B, and pneumococcal conjugate vaccines in their second year.
- Doses of poliovirus and diphtheria-tetanus-acellular pertussis (DTaP) are due before 19 months and again at 4-6 years.
Conclusions:
- Adherence to the recommended childhood immunization schedule is vital for comprehensive disease prevention.
- Vaccines provide both immediate and long-term protection against various infectious diseases.
- Understanding vaccine timing ensures optimal immune response and public health safety.
Abstract:
In addition to the vaccines due in the first year of life, the US Advisory Committee on Immunization Practices recommends that children continue to receive vaccines regularly against a variety of infectious diseases. Starting at 12 to 15 months of life, these include the two-dose measles-mumps-rubella vaccine series and the two-dose varicella vaccine series. Also in the second year of life, infants should begin the two-dose hepatitis A vaccine series and complete the Haemophilus influenzae type B vaccine series as well as the pneumococcal conjugate vaccine series. Before 19 months of life, infants should receive the third dose of the poliovirus vaccine and the fourth dose of diphtheria-tetanus-acellular pertussis (DTaP) vaccine. The final doses of poliovirus and tetanus-diphtheria-acellular pertussis vaccines are both due at 4 to 6 years of life. Before each influenza season, every child should receive the influenza vaccine. Those less than 9 years of age who previously received less than two doses need two doses a month apart. At 11 to 12 years of life, all should get two doses of the human papillomavirus vaccine, the adolescent/adult version of the tetanus-diphtheria-acellular pertussis vaccine, and begin a two-dose series of meningococcal ACWY vaccine. Each of these vaccines is due when the vaccine works to protect against both an immediate risk as well as to provide long-term protection. Each vaccine-preventable disease varies in terms of the nature of exposure, the form of the morbidity, the risk of mortality, and potential to prevent or ameliorate its harm.
Related Concept Videos
Vaccinations
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Drug Excretion
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Microorganisms in Medicine and Therapeutics
Active versus Passive Immunity
Active Immunity
Active immunity refers to the resistance one develops...

