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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Related Experiment Video

Updated: Dec 13, 2025

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
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Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

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Radioresistant tumours: From identification to targeting.

É Cohen-Jonathan-Moyal1, V Vendrely2, L Motte3

  • 1Department of radiation oncology, institut Claudius-Regaud, IUCT-O, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Inserm UMR 1037, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France; Centre de recherches en cancérologie de Toulouse, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|August 6, 2020
PubMed
Summary
This summary is machine-generated.

Tumour radioresistance mechanisms involve complex biological factors. Advanced imaging and novel radiotherapy approaches, including high-energy particles and nanoparticles, show promise for overcoming treatment resistance.

Keywords:
Dose paintingDose prescriptionHadrontherapyHadronthérapieHeterogeneityHétérogénéitéModulationNanoparticulePrescription de doseRadioresistanceRadiorésistanceRadiotherapyRadiothérapieTargetingTheranosticsThéranostiqueTumeurTumour

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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Imaging

Background:

  • Tumour radioresistance is a complex challenge in radiation oncology, influenced by various biological factors.
  • Mechanisms include oncogenic signaling, metabolism, proliferation, tumor microenvironment (hypoxia), and genomics.
  • Understanding these factors is crucial for improving radiotherapy outcomes.

Purpose of the Study:

  • To review the multifaceted mechanisms of tumour radioresistance.
  • To explore theragnostic approaches linking tumour biology and imaging.
  • To discuss advanced radiotherapy strategies for overcoming radioresistance.

Main Methods:

  • Literature review of tumour radioresistance mechanisms.
  • Discussion of theragnostic applications using biological imaging and biomarkers.
  • Analysis of dose prescription modeling and advanced particle therapy techniques.

Main Results:

  • Identified key mechanisms of radioresistance: oncogenic pathways, metabolism, hypoxia, and genomics.
  • Highlighted the potential of theragnostic approaches correlating tumour histology with imaging.
  • Investigated dose painting strategies and limitations of low lineal energy transfer particles.

Conclusions:

  • Overcoming tumour radioresistance requires a comprehensive understanding of its underlying biological mechanisms.
  • Theranostic imaging and advanced radiotherapy techniques, such as high lineal energy transfer particles or nanoparticles, offer promising avenues for enhancing tumour curability.