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Updated: Dec 13, 2025

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
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Kounis syndrome: A rare case.

Ashok Sunder1, Bijaya Mohanty1, Abha Singh1

  • 1Department of Medicine, Tata Main Hospital, Jamshedpur, Jharkhand, India.

Journal of Family Medicine and Primary Care
|August 6, 2020
PubMed
Summary

Kounis syndrome, a mast cell activation disorder, can cause allergic angina and myocardial infarction. This case highlights a patient diagnosed with Kounis syndrome following a bee sting, presenting with dyspnea and chest heaviness.

Keywords:
Allergic myocardial infarctionKounis syndromevasospastic

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Area of Science:

  • Cardiology
  • Allergy and Immunology
  • Mast Cell Activation Disorders

Background:

  • Kounis syndrome encompasses allergic angina and myocardial infarction, linked to mast cell activation disorders.
  • These conditions are associated with acute coronary syndromes, presenting a diagnostic challenge.

Observation:

  • A patient presented with dyspnea and mild chest heaviness after a bee sting.
  • The clinical presentation mimicked acute coronary syndromes.

Findings:

  • The patient was diagnosed with Kounis syndrome, a rare manifestation of allergic reaction.
  • Bee sting acted as a trigger for mast cell degranulation, leading to coronary artery spasm.

Implications:

  • This case underscores the importance of considering Kounis syndrome in patients with acute coronary syndromes and allergic triggers.
  • Early diagnosis and management are crucial for preventing severe cardiac events.
  • Raising awareness among clinicians about this syndrome can improve patient outcomes.