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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Invasive Aspergillosis as an Under-recognized Superinfection in COVID-19

George R Thompson Iii1,2, Oliver A Cornely3,4,5,6, Peter G Pappas7

  • 1Department of Internal Medicine, University of California Davis Medical Center, Davis, California, USA.

Open Forum Infectious Diseases
|August 6, 2020
PubMed

Insights

Pulmonary aspergillosis is a growing concern after severe respiratory viral infections like COVID-19. Early identification of COVID-19 associated pulmonary aspergillosis (CAPA) is crucial for better patient outcomes.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Pulmonary aspergillosis incidence rises after severe respiratory viral infections.
  • Millions infected with SARS-CoV-2 are at risk for COVID-19 associated pulmonary aspergillosis (CAPA).

Purpose of the Study:

  • To highlight the increasing association between SARS-CoV-2 and pulmonary aspergillosis.
  • To emphasize the critical need for prompt recognition of CAPA.

Main Methods:

  • Review of recent clinical reports and epidemiological data.
  • Analysis of risk factors and clinical presentation of CAPA.

Main Results:

  • Significant increase in reported cases of pulmonary aspergillosis post-SARS-CoV-2 infection.
  • CAPA identified as a serious complication in COVID-19 patients.

Conclusions:

  • Early diagnosis and management of CAPA are essential.
  • Increased vigilance for fungal co-infections in respiratory viral pandemics is warranted.

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