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Published on: December 19, 2020
Pathological features of COVID-19 infection from biopsy and autopsy series
Sidar Çopur1, Asiye Kanbay2, Barış Afşar3
1Department of Internal Medicine, Faculty of Medicine, Koc University, Istanbul, Turkey.
Insights
This study reviews the pathology of COVID-19 (coronavirus disease 2019) by examining biopsy and autopsy findings. Understanding these pathological features is crucial for improving patient outcomes and developing new treatments for SARS-CoV-2 infection.
Area of Science:
- Pathology
- Infectious Diseases
- Pulmonology
Background:
- Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, emerged in late 2019 and rapidly became a global pandemic.
- The disease presents with diverse symptoms, ranging from mild to severe, including pneumonia, multi-organ failure, and hypoxemic respiratory failure.
- Accumulating evidence from biopsy and autopsy studies indicates that COVID-19 can affect multiple organs.
Purpose of the Study:
- To summarize the pathological features of COVID-19.
- To provide insights into the organ-specific manifestations of the disease.
- To highlight the importance of pathological studies in understanding clinical outcomes and therapeutic development.
Main Methods:
- Review of biopsy series.
- Analysis of autopsy series.
- Synthesis of pathological findings from existing literature.
Main Results:
- Detailed description of pathological changes observed in various organs due to SARS-CoV-2 infection.
- Identification of common and severe pathological patterns associated with COVID-19.
- Correlation of pathological findings with clinical manifestations and mortality causes.
Conclusions:
- Pathological examination of biopsy and autopsy samples is essential for a comprehensive understanding of COVID-19.
- Pathological insights can guide the development of targeted therapies and improve patient management strategies.
- Further research into the detailed pathology of COVID-19 is warranted.
Abstract:
Novel coronavirus disease 2019 (COVID-19) which is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) was first identified in December 2019 in Chinese town Wuhan and considered as a pandemic by World Health Organization. The disease has variety of symptoms including fever, shortness of breath, cough, fatigue, loss of smell and taste and diarrhea. While the majority of cases have mild symptoms, some progress to viral pneumonia, multi-organ failure, or cytokine storm and mortality is mostly caused by hypoxemic respiratory failure. Until now, more than 3.5 million people worldwide were infected and more than 240.000 mortality has been occurred. Thus, there is now evidence the disease may affect variety of organs according to accumulating biopsy and autopsy studies. Such pathological studies have potential role on the understanding of clinical outcomes and in the development of novel targeted therapeutic approaches. Given these aforementioned data, in the current manuscript we have summarized the pathological features of COVID-19 derived from biopsy and autopsy series.
