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A rare but a serious complication: gemifloxacin induced tendinopathy

Asiye Kanbay1, İrem Mıhcıoğlu2, Nilüfer Tekin3

  • 1Department of Chest Diseases, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Tuberkuloz Ve Toraks
|August 6, 2020
PubMed

Insights

Gemifloxacin, an antibiotic, can rarely cause tendon rupture and bleeding. This fluoroquinolone adverse effect most often impacts the Achilles tendon, especially in older patients or those with specific health conditions.

Area of Science:

  • Pharmacology
  • Orthopedics
  • Infectious Diseases

Background:

  • Antibiotics, specifically fluoroquinolones, are widely used for bacterial infections.
  • Tendinopathy is a known, albeit rare, adverse effect associated with fluoroquinolone use.
  • Lower respiratory tract infections are common indications for antibiotic therapy.

Observation:

  • A case of tendon rupture and subcutaneous bleeding occurred post-gemifloxacin administration.
  • Gemifloxacin is a fluoroquinolone antibiotic used for respiratory infections.

Findings:

  • Fluoroquinolone-induced tendinopathy is an increasingly recognized complication.
  • The Achilles tendon is the most commonly affected site, with potential for complete rupture.
  • Predisposing factors include concurrent steroid use, renal failure, kidney transplantation, advanced age, and athletic activity.

Implications:

  • Clinicians should be aware of the risk of tendinopathy with fluoroquinolone use.
  • Patient history, including steroid use and renal function, should be considered when prescribing these antibiotics.
  • Early recognition and management of tendinopathy are crucial to prevent severe outcomes like tendon rupture.

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