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Related Experiment Video

Updated: Dec 13, 2025

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Prone Versus Upright Digital Tomosynthesis-Guided Biopsy.

Sadia Choudhery1, Matthew Johnson2, Robert T Fazzio1

  • 1Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

AJR. American Journal of Roentgenology
|August 7, 2020
PubMed
Summary

Prone and upright digital breast tomosynthesis (DBT)-guided biopsies show similar clinical performance, with upright methods requiring fewer exposures. Factors like patient comfort and room use should guide technique selection.

Keywords:
biopsybreastdigital breast tomosynthesismammographytechnology assessment

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Area of Science:

  • Radiology
  • Medical Imaging
  • Breast Cancer Diagnostics

Background:

  • Digital breast tomosynthesis (DBT) is an advanced imaging technique for breast cancer detection.
  • Both prone and upright positions are utilized for DBT-guided breast biopsies.
  • Comparative performance data between these positioning methods is crucial for optimizing biopsy procedures.

Purpose of the Study:

  • To compare the clinical performance of digital breast tomosynthesis (DBT)-guided prone versus upright breast biopsies.
  • To identify differences in key procedural metrics and outcomes between the two biopsy techniques.

Main Methods:

  • Retrospective review of 282 consecutive DBT-guided breast biopsies performed between May 2018 and July 2019.
  • Data collected included patient demographics, biopsy details, procedural metrics (samples, exposures, time), complications, and histopathology.
  • Statistical comparison using chi-square and Wilcoxon rank sum tests to evaluate differences between prone and upright methods.

Main Results:

  • All 282 biopsies (215 prone, 67 upright) were technically successful.
  • Upright DBT-guided biopsies required significantly fewer mean exposures compared to prone biopsies (p < 0.001).
  • No significant differences were observed in mean samples acquired, procedure time, calcification removal, or complication rates.

Conclusions:

  • Prone and upright DBT-guided breast biopsies demonstrate comparable clinical performance regarding diagnostic yield and safety.
  • The number of exposures is a key differentiator, with upright biopsies being more efficient in this regard.
  • Selection between prone and upright positioning should incorporate factors beyond technical performance, such as room utilization and patient comfort.