Related Experiment Video
Updated: Jul 2, 2026
In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Blast exposure results in tau and neurofilament light chain changes in peripheral blood
Katie A Edwards1,2, Jacqueline J Leete1, Anna E Tschiffely3
1National Institute of Nursing Research, National Institutes of Health , Bethesda, MD, USA.
Objectives:
To evaluate how blast exposure impacts peripheral biomarkers.
Abstract:
in military personnel enrolled in 10-day blast training.
Methods:
On day 7, 21 military personnel experienced peak overpressure <2 pounds per square inch (psi); while 29 military personnel experienced peak overpressure ≥5 psi. Blood samples were collected each day to measure changes in amyloid beta (Aβ), neurofilament light chain (NFL), and tau concentrations.
Results:
Within 24 hours following exposure ≥5 psi, the ≥5 psi group had lower Aβ42 (p = .004) and NFL (p < .001) compared to the <2 psi group and lower Aβ42 (9.35%) and NFL (22.01%) compared to baseline. Twenty-four hours after ≥5 psi exposure, the ≥5 psi group had lower tau (p < .001) and NFL (p < .001) compared to the <2 psi group and baseline. Seventy-two hours after exposure ≥5 psi, tau increased in the ≥5 psi group compared to the <2 psi group (p = .02) and baseline. The tau:Aβ42 ratio 24 hours after blast (p = .012), and the Aβ40:Aβ42 ratio 48 hours after blast (p = .04) differed in the ≥5 psi group compared to the <2 psi group.
Conclusions:
These findings provide an initial report of acute alterations in biomarker concentrations following blast exposure.
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