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Solventless granulation and spheronization of indomethacin crystals using a mechanical powder processor: Effects of

Keita Kondo1, Koki Miyamoto1, Sayaka Miura1

  • 1Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|August 7, 2020
PubMed

Keywords:
AdhesivenessDry granulationGlass transitionMechanical powder processorMechanically-induced amorphizationParticle shape modificationRecrystallizationSolventless spheronizationStiffnessdrug particle formationmechanical powder processingamorphous drug propertiespharmaceutical agglomeration

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