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Published on: January 28, 2020
Vitamin D for inflammation biomarkers in coronary artery disease: A protocol for systematic review and meta-analysis
Yiru Wang1, Yifan Zhang1, Jing Wei2
1Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine.
Insights
This systematic review examines Vitamin D supplementation
Area of Science:
- Cardiology
- Endocrinology
- Nutritional Science
Background:
- Coronary artery disease (CAD) is a prevalent cardiovascular condition.
- Vitamin D may offer benefits to CAD patients by modulating inflammation.
- This study investigates Vitamin D's impact on inflammatory markers in CAD.
Purpose of the Study:
- To systematically review the effects of Vitamin D supplementation on inflammatory markers in patients with coronary artery disease.
- To evaluate Vitamin D's efficacy in managing inflammation associated with CAD.
Main Methods:
- Systematic literature search of electronic databases and reference lists.
- Independent screening and data extraction by two investigators.
- Analysis of primary outcomes (inflammatory biomarkers) and secondary outcomes (lipid profile, blood pressure).
Main Results:
- The study aims to provide reliable evidence on Vitamin D's efficacy in reducing inflammation in CAD patients.
- Results will assess the impact of Vitamin D on key inflammatory biomarkers.
Conclusions:
- The review will determine if Vitamin D supplementation is an effective intervention for reducing inflammation in coronary artery disease patients.
- Findings will inform clinical practice regarding Vitamin D use in CAD management.
Background:
Coronary artery disease (CAD) is a clinically common coronary heart disease. Vitamin D might be beneficial in CAD patients through its favorable effects on inflammation biomarkers. This study will be performed to examine the effects of Vitamin D supplementation on inflammatory markers in CAD patients.
Methods:
We will search the electronical databases and hand-searching journals or reference lists. The study screening and data extraction will be carried out by 2 investigators independently. The primary outcome is inflammatory biomarkers of peripheral blood. Secondary outcomes are triglyceride, total cholesterol, high-density lipoprotein cholesterol levels, low-density lipoprotein cholesterol, and blood pressure. Review Manager (RevMan, version 5.3; The Nordic Cochrane Centre, Copenhagen, Denmark: http://community.cochrane.org) V.5.3 software will be used to compute the data.
Results:
The results of the study will provide a reliable evidence to assess the efficacy of Vitamin D supplement on inflammation biomarkers of CAD patients.
Conclusion:
The conclusion of our systematic review will answer whether Vitamin D is an effective intervention to relieve inflammation of CAD patients.
Ethics:
Because all of the data used in this review has been published, this review does not require ethical approval.
Registration Number:
INPLASY202060072.
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