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MMP-9-C1562T polymorphism and susceptibility to chronic obstructive pulmonary disease: A meta-analysis
Rongrong Zhao1, Houxiu Zhou, Jingci Zhu
1Department of Nursing, Army Medical University (Third Military Medical University), Chong Qing, China.
Background:
To comprehensively evaluate the association between the polymorphism of matrix metalloproteinase-9 (MMP-9)-C1562T (rs3918242) and susceptibility to chronic obstructive pulmonary disease (COPD) in middle-aged and elderly patients through Meta-analysis.
Methods:
PubMed, EMBASE, CNKI, Wanfang, VIP, and other databases were searched by computer in the inception to August 2019 to collect all the case-control studies that met the inclusion criteria in this literature. Meta-analysis was performed using Stata 15.0, including the OR value calculations of the association between the merged MMP-9-C1562T polymorphism and the COPD susceptibility. Subgroup analysis, sensitivity analysis, and publication bias test were also performed. A total of 13 literature were included in this Meta-analysis with a total of 2512 cases and 2716 controls.
Results:
The results have shown that the OR of MMP-9-C1562T T allele to C allele was 0.35 (95% confidence interval [CI]: 0.23-0.52, P < .01). The subgroup analysis of ethnicity result showed that the merged OR of MMP-9-C1562T T allele to C allele was 0.24 (95% CI: 0.17-0.34, P < .01) in Caucasian while the merged OR was 0.62 (95% CI: 0.22-1.70, P > .05) in Asian. However, there were no statistically significant models in the dominant, recessive, homozygote and heterozygote genetic models.
Conclusion:
The MMP-9-C1562T polymorphism was associated with the susceptibility to middle-aged and elderly COPD patients. Compared with T allele, C allele increased the risk of disease, especially in Caucasian, but not found in Asian.
Insights
The matrix metalloproteinase-9 (MMP-9) C1562T gene polymorphism is linked to chronic obstructive pulmonary disease (COPD) risk in middle-aged and elderly individuals. The C allele increases COPD susceptibility, particularly in Caucasians, while the T allele shows a protective effect.
Area of Science:
- Genetics
- Pulmonology
- Molecular Biology
Background:
- Chronic obstructive pulmonary disease (COPD) is a major global health concern.
- Genetic factors, including matrix metalloproteinase-9 (MMP-9) gene polymorphisms, are implicated in COPD susceptibility.
- The MMP-9 C1562T (rs3918242) polymorphism has been investigated for its association with COPD risk.
Purpose of the Study:
- To conduct a meta-analysis evaluating the association between the MMP-9 C1562T polymorphism and COPD susceptibility.
- To assess the role of this polymorphism in middle-aged and elderly COPD patients.
- To explore ethnic differences in the MMP-9 C1562T polymorphism's association with COPD.
Main Methods:
- A comprehensive literature search was performed across multiple databases (PubMed, EMBASE, CNKI, Wanfang, VIP) up to August 2019.
- Case-control studies investigating the MMP-9 C1562T polymorphism and COPD were included.
- Meta-analysis was conducted using Stata 15.0, including subgroup and sensitivity analyses, and publication bias tests.
Main Results:
- The meta-analysis included 13 studies with 2512 cases and 2716 controls.
- A significant association was found between the MMP-9 C1562T polymorphism and COPD susceptibility (OR=0.35, P<.01).
- Subgroup analysis revealed a stronger association in Caucasians (OR=0.24, P<.01) but not in Asians (OR=0.62, P>.05).
Conclusions:
- The MMP-9 C1562T polymorphism is associated with COPD susceptibility in middle-aged and elderly populations.
- The C allele appears to increase COPD risk, especially in Caucasians.
- No significant association was observed in the Asian population.
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