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Association of matrix metalloproteinase-12 polymorphisms with chronic obstructive pulmonary disease risk: A protocol
Hongjing Yang1, Chuantao Zhang1, Jianying Wu2
1Department of Respiratory Medicine.
Background:
Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with gene-environment interaction leading to airflow limitation through the respiratory tract. Reports on the association of matrix metalloproteinase 12 (MMP-12) polymorphisms with COPD have been controversial. A new systematic evaluation which could examine whether MMP-12 mutations are associated with the susceptibility to COPD is needed.
Methods:
We will search PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure and Google Scholar to obtain eligible case-control studies for meta-analysis. The time is limited from the construction of the library to July 2020. Two investigators systematically will extract relevant data within those included studies.The odds ratio and 95% confidence intervals will be used to assess the genetic association between the allelic, dominant and recessive models of MMP-12 gene polymorphisms and COPD risk. Stata 12.0 software and Revman 5.3 will be adopted for statistical analysis. This protocol reported under the Preferred Reporting ltems for Systematic Reviews and Meta-Analyses Protocols statement.
Results:
This study will provide a better understanding of the association between MMP-12 polymorphisms and COPD risk.
Conclusion:
Publishing this protocol will minimise the possibility of bias due to post hoc changes to the analysis protocol.
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