Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcription attenuation.

C Yanofsky1

  • 1Department of Biological Sciences, Stanford University, California 94305-5020.

The Journal of Biological Chemistry
|January 15, 1988
PubMed
Summary
This summary is machine-generated.

Prokaryotic transcription attenuation uses metabolic signals to control gene expression by regulating transcription termination. This mechanism, involving sensing events, also has potential eukaryotic parallels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel approach to speed up peptide sequencing via MS/MS spectra analysis.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
Same author

Surface analysis of peptide mass spectra to improve time and mass localization.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
Same author

New insights into regulation of the tryptophan biosynthetic operon in Gram-positive bacteria.

Trends in genetics : TIG·2005
Same author

Inhibition of the B. subtilis regulatory protein TRAP by the TRAP-inhibitory protein, AT.

Science (New York, N.Y.)·2001
Same author

The mechanism of tryptophan induction of tryptophanase operon expression: tryptophan inhibits release factor-mediated cleavage of TnaC-peptidyl-tRNA(Pro).

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Advancing our knowledge in biochemistry, genetics, and microbiology through studies on tryptophan metabolism.

Annual review of biochemistry·2001

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Transcription regulation is crucial for cellular function.
  • Attenuation is a key mechanism controlling gene expression in prokaryotes.
  • Metabolic signals often dictate the need for specific gene products.

Purpose of the Study:

  • To describe prokaryotic transcription attenuation mechanisms.
  • To highlight the role of metabolic signals and sensing events in regulating transcription termination.
  • To explore potential eukaryotic examples of similar regulatory strategies.

Main Methods:

  • Review and synthesis of existing literature on prokaryotic transcription attenuation.
  • Analysis of specific examples of metabolic signal-mediated regulation.

Related Experiment Videos

  • Comparative analysis to identify potential eukaryotic analogues.

    • Main Results:

    • Detailed description of how metabolic signals trigger transcription termination in prokaryotes.
    • Identification of sensing events linked to specific metabolic states.
    • Presentation of suggestive eukaryotic systems exhibiting similar regulatory principles.

    Conclusions:

    • Prokaryotic transcription attenuation is a sophisticated regulatory network.
    • Metabolic status directly influences gene expression through termination control.
    • Eukaryotic systems may employ analogous mechanisms for fine-tuning gene expression.