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Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function

Kelly Tan1, Jonathan Coppeta, Hesham Azizgolshani

  • 1Draper, 555 Technology Square, Cambridge, MA 02138, USA. jcharest@draper.com sbale@draper.com.

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Summary

This study corrects a previous publication on the PREDICT-96 system. The PREDICT-96 is a microfluidic device designed to mimic liver function under dynamic flow conditions for high-throughput drug screening.

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Area of Science:

  • Biomedical Engineering
  • Hepatology
  • Microfluidics

Background:

  • Microphysiological systems (MPS) are crucial for drug development.
  • Recapitulating liver function in vitro remains challenging.
  • Previous work introduced the PREDICT-96 system for high-throughput liver studies.

Purpose of the Study:

  • To provide corrections to a previously published article.
  • To ensure accurate representation of the PREDICT-96 system's capabilities.
  • To maintain the integrity of research using this microfluidic platform.

Main Methods:

  • Correction of specific details within the original publication.
  • Re-evaluation of data presentation and interpretation.
  • Clarification of system parameters and experimental conditions.

Main Results:

  • Identified and corrected inaccuracies in the original manuscript.
  • Ensured the accurate depiction of hepatocyte function in the PREDICT-96 system.
  • Confirmed the system's utility for dynamic, re-circulating flow studies.

Conclusions:

  • The corrected information ensures the reliable use of the PREDICT-96 system.
  • Accurate data is vital for advancing drug discovery and liver research.
  • This correction upholds the scientific rigor of microphysiological system research.