Related Experiment Video

Updated: Dec 12, 2025

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
07:40

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

1.5K

Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC-1α pathway

Ying Mei1, Bo Liu1, Hao Su1

  • 1Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.

Journal of Cellular and Molecular Medicine
|August 7, 2020
PubMed

Insights

Isosteviol sodium (STVNa) protects cardiomyocytes from damage by reducing oxidative stress and enhancing mitochondrial function. This cardioprotective effect involves the SIRT1/PGC-1α pathway, offering potential for treating heart dysfunction.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • Cardiomyocyte dysfunction arises from oxidative damage, with underlying molecular pathways needing further elucidation.
  • Isosteviol sodium (STVNa) shows promise for cardioprotection, but its specific mechanisms are not fully understood.

Purpose of the Study:

  • To investigate the effects of STVNa on cardiomyocytes and elucidate its protective mechanisms.
  • To explore STVNa's role in mitigating myocardial hypertrophy induced by high glucose (HG) and isoprenaline (ISO).

Main Methods:

  • Established myocardial hypertrophy models using H9c2 cells treated with HG and ISO.
  • Assessed STVNa's impact on mitochondrial damage, morphology, and biogenesis.
  • Investigated the involvement of the SIRT1/PGC-1α signaling pathway, using SIRT1 modulators.

Main Results:

  • STVNa attenuated oxidative damage and improved mitochondrial morphology in H9c2 cells.
  • STVNa promoted mitochondrial biogenesis, counteracting HG- and ISO-induced damage.
  • STVNa's cardioprotective effects were linked to SIRT1/PGC-1α pathway regulation, with distinct modulation in different models.

Conclusions:

  • STVNa demonstrates significant cardioprotective effects against oxidative stress and mitochondrial dysfunction.
  • The SIRT1/PGC-1α pathway is a key mediator of STVNa's benefits in cardiomyocyte hypertrophy.
  • STVNa presents a potential therapeutic strategy for preventing and treating cardiomyocyte dysfunction.
Keywords:
PGC-1αSIRT1cardiomyocyte dysfunctionisosteviol sodiummitochondria

More Related Videos

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice08:03

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Published on: March 30, 2022

1.9K
Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.9K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
244
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
316
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
293