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Assessment of ventricular dysfunction in Egyptian children with Beta-thalassemia major

Salem E Deraz1, Sameh A Abd El Naby1, Asmaa A Mahmoud1

  • 1Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.

Hematology/Oncology and Stem Cell Therapy
|August 8, 2020
PubMed

Insights

Children with beta-thalassemia major show elevated cardiac biomarkers and altered heart function. Tissue Doppler imaging and NT pro-BNP effectively detect ventricular dysfunction in these patients.

Area of Science:

  • Cardiology
  • Pediatrics
  • Hematology

Background:

  • Beta-thalassemia major (β-TM) patients on regular transfusions face cardiac iron toxicity, a leading cause of heart failure.
  • Assessing cardiovascular changes is crucial for managing β-TM complications.

Purpose of the Study:

  • To evaluate serum cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.
  • To assess the utility of tissue Doppler imaging (TDI) in detecting left ventricular (LV) dysfunction in children with β-TM.

Main Methods:

  • A cross-sectional study involving 50 children with β-TM and 50 healthy controls.
  • Measurements included serum ferritin, cTnI, NT-proBNP, and comprehensive TDI parameters.

Main Results:

  • Patients with β-TM exhibited significantly increased NT-proBNP and cTnI levels.
  • TDI revealed LV dilation, increased LV mass, altered diastolic function (E/A ratio, deceleration time), and impaired myocardial velocities (Em, Sm).
  • NT-proBNP positively correlated with E wave, E/A ratio, E/Em ratio, and ferritin levels.

Conclusions:

  • Pulsed wave TDI and NT-proBNP are valuable tools for estimating ventricular dysfunction in pediatric β-TM.
  • These methods aid in early detection and management of cardiac complications in β-TM.
Abstract

Keywords:
Beta-thalassemia majorCardiac troponin IIron overloadN-terminal pro-brain natriuretic peptideTissue doppler imaging

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