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Marburg virus disease: A summary for clinicians
Mark G Kortepeter1, Kerry Dierberg2, Erica S Shenoy3
1University of Nebraska Medical Center, Omaha, NE, USA.
Summary
This review highlights six treatments and four vaccine platforms showing promise for Marburg virus disease (MVD) based on nonhuman primate and human data. These Marburg virus countermeasures offer potential emergency use for MVD prevention and treatment.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Marburg virus disease (MVD) is a severe hemorrhagic fever with high mortality.
- Limited effective countermeasures currently exist for MVD outbreaks.
Purpose of the Study:
- To summarize current and emerging countermeasures for Marburg virus disease.
- To focus on therapies and vaccines with demonstrated potential for emergency use.
Main Methods:
- A standardized literature review was performed.
- Focused on Marburg virus disease vaccines and treatments.
- Included human and nonhuman primate data from the last five years.
Main Results:
- Identified six promising treatments for MVD.
- Identified four vaccine platforms with potential efficacy.
- Efficacy data primarily from nonhuman primate studies.
Conclusions:
- Summarized Marburg countermeasures for clinicians.
- Provided links to authoritative information sources.
- Aimed to facilitate rapid understanding for MVD patient management.
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