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Clopidogrel preventive effect based on cytochrome P450 2C19 genotype in ischaemic stroke: protocol for multicentre
Tae-Jin Song1, Jinkwon Kim2, Sang Won Han3
1Department of Neurology, Seoul Hospital, College of Medicine, Ewha Womans University, Seoul, South Korea.
BMJ Open
|August 8, 2020
Summary
Patients with a loss-of-function CYP2C19 genotype taking clopidogrel after stroke may face higher cardiovascular event risks. This study investigates CYP2C19 genotype
Area of Science:
- Pharmacogenomics
- Cardiovascular Medicine
- Neurology
Background:
- Clopidogrel is vital for preventing cardiovascular and cerebrovascular events.
- Cytochrome P450 2C19 (CYP2C19) genotype influences clopidogrel metabolism and efficacy.
- The impact of CYP2C19 genotype on clopidogrel's efficacy in stroke patients is not well understood.
Purpose of the Study:
- To investigate whether CYP2C19 genotype affects clopidogrel's preventive efficacy in acute ischemic stroke patients.
- To compare the risk of composite cardiovascular events between poor/intermediate and extensive CYP2C19 metabolizers.
Main Methods:
- Prospective, observational, multicenter study.
- Inclusion: acute ischemic stroke patients receiving clopidogrel within 72 hours and CYP2C19 genotype evaluation.
- Primary outcome: composite cardiovascular events (stroke, myocardial infarction, cardiovascular death) within 6 months.
Main Results:
- This section is to be filled once the study is completed and results are available.
Conclusions:
- This section is to be filled once the study is completed and results are available.
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