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Two Patients With Meigs' Syndrome and Elevated Serum CA-125: A Case Report
Javier Navarro-Esteva1, Maria Laseca-Modrago2, Octavio Arencibia-Sánchez2
1Pulmonary Medicine, Hospital San Roque Maspalomas, Maspalomas, Las Palmas de GC, ESP.
Cureus
|August 8, 2020
Summary
Meigs
Area of Science:
- Gynecology
- Oncology
- Pulmonology
Background:
- Meigs' syndrome, characterized by a benign ovarian tumor, ascites, and pleural effusion, is rare.
- Elevated serum cancer antigen 125 (CA-125) levels are typically associated with malignancy, complicating Meigs' syndrome diagnosis.
Observation:
- Two patients presented with shortness of breath due to pleural effusion, with pelvic masses identified.
- Both patients exhibited elevated serum CA-125 levels, initially suggesting ovarian cancer.
Findings:
- Post-surgical pathology revealed a benign ovarian neoplasm in one patient and a low-grade malignant neoplasm in the other.
- Complete tumor resection resolved the pleural effusion and ascites in both cases.
Implications:
- This case series highlights that elevated CA-125 does not always indicate advanced malignancy in Meigs' syndrome.
- Accurate diagnosis and surgical management are crucial for favorable outcomes in patients presenting with Meigs' syndrome and elevated CA-125.
- Further research into the diagnostic utility of CA-125 in Meigs' syndrome is warranted.
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