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Microfluidic lumen-based systems for advancing tubular organ modeling.

María Virumbrales-Muñoz1, José M Ayuso2, Max M Gong3

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Microfluidic lumen-based systems are advanced microscale models that mimic tubular organs. These models significantly impact drug discovery by simulating human diseases and predicting drug responses.

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Area of Science:

  • Biomedical Engineering
  • Organ-on-a-chip Technology
  • Microfluidics

Background:

  • Microfluidic lumen-based systems are microscale models that replicate tubular organ anatomy and physiology.
  • These systems offer a platform to mimic human pathophysiology and predict drug responses.
  • They hold significant implications for drug discovery and development.

Purpose of the Study:

  • To review the progress in the development of microfluidic lumen-based models since the 2000s.
  • To discuss the application of these models in mimicking various organ systems and diseases.
  • To highlight emerging applications and future directions in the field.

Main Methods:

  • Review of scientific literature on microfluidic lumen-based systems.
  • Analysis of models for blood vessels, respiratory tract, gastrointestinal tract, renal tubules, and liver sinusoids.
  • Discussion of applications in organ-specific disease modeling.

Main Results:

  • Significant advancements in microfluidic lumen-based models for various organs.
  • Demonstrated utility in recapitulating organ-specific pathophysiology and disease states.
  • Emerging applications in areas like the lymphatic system.

Conclusions:

  • Microfluidic lumen-based systems have evolved significantly, offering powerful tools for biomedical research.
  • These models are crucial for advancing drug discovery and development through better prediction of drug responses.
  • Future directions include expanding applications to more complex systems and diseases.