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Related Experiment Videos

Decrease in frequency of anginal episodes by control of thrombin generation with low-dose heparin: a controlled

G G Neri Serneri1, R Abbate, D Prisco

  • 1Clinica Medica I, University of Florence, Italy.

American Heart Journal
|January 1, 1988
PubMed
Summary
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Low-dose heparin effectively controls thrombin generation, significantly reducing anginal activity in patients with spontaneous angina. This treatment improves symptoms and increases symptomless periods, indicating a favorable impact on anginal disease management.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Increased thrombin generation correlates with heightened anginal activity.
  • Spontaneous angina requires effective management strategies to control thrombin generation.

Purpose of the Study:

  • To investigate if controlling thrombin generation with low-dose heparin impacts anginal activity.
  • To evaluate the efficacy of heparin in managing spontaneous angina.

Main Methods:

  • A 12-month, randomized, single-blind, cross-over study involving 24 angina patients.
  • Patients received either low-dose heparin (12,500 IU subcutaneously) or placebo for 6-month periods.
  • Thrombin generation (fibrinopeptide A levels) and anginal activity were assessed bi-weekly.

Main Results:

Related Experiment Videos

  • Low-dose heparin significantly reduced fibrinopeptide A plasma levels (p < 0.001).
  • Heparin treatment led to a 53% decrease in severely symptomatic angina and a 30% decrease in mildly symptomatic angina.
  • The symptomless angina class increased by 23% during heparin treatment (p < 0.001).

Conclusions:

  • Controlling thrombin generation with low-dose heparin favorably impacts anginal activity in spontaneous angina patients.
  • Heparin therapy offers a viable strategy for managing angina by targeting thrombin generation.