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Pericarditis II: Clinical Features and Diagnostic Tests01:19

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Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
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Specific inflammatory profile in each pregnancy complication: A comparative study.

Marie-Eve Brien1,2,3, Ines Boufaied1, Nathalie Bernard4

  • 1Ste-Justine Hospital Research Center, Montreal, QC, Canada.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|August 8, 2020
PubMed
Summary
This summary is machine-generated.

Pregnancy complications like pre-eclampsia, preterm birth, and IUGR show distinct inflammatory profiles. These inflammatory changes, even in normal pregnancies, help differentiate pathological conditions and understand their clinical presentation.

Keywords:
alarminscytokineinflammationinflammatory mediatorsintra-uterine growth restrictionpre-eclampsiapregnancypreterm birth

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Area of Science:

  • Reproductive biology and immunology
  • Maternal-fetal medicine
  • Biomarker discovery in pregnancy

Background:

  • Pre-eclampsia, preterm birth, and intra-uterine growth restriction affect 5%-12% of pregnancies.
  • These conditions are linked to placental inflammation, but circulating inflammatory mediators remain controversial.
  • Understanding inflammatory changes in the second half of pregnancy is crucial for distinguishing these complications.

Purpose of the Study:

  • To investigate inflammatory changes during the second half of pregnancy.
  • To identify specific inflammatory profiles associated with pre-eclampsia, preterm birth, and intra-uterine growth restriction.
  • To differentiate pathological pregnancies from uncomplicated pregnancies based on inflammatory markers.

Main Methods:

  • Nested case-control study of 200 women (50 each for uncomplicated pregnancy, pre-eclampsia, preterm birth, IUGR).
  • Plasma samples analyzed for over 30 mediators (cytokines, alarmins) in the late second trimester and at delivery.
  • Analysis included multiplex, ELISA, and specific assays, alongside demographic and obstetrical data.

Main Results:

  • Uncomplicated pregnancies showed increased inflammatory mediators (e.g., MCP-1, IL-6) towards term, indicating a pro-inflammatory profile.
  • Pre-eclampsia cases exhibited elevated IL-6, CXCL10, and CRP compared to controls.
  • Preterm birth was associated with increased second-trimester CXCL9 and decreased delivery progesterone; IUGR showed increased second-trimester HMGB1 and IL-1α.

Conclusions:

  • Normal pregnancy progression involves inflammatory changes, but pathological pregnancies display distinct and more pronounced inflammatory profiles.
  • Specific inflammatory mediator patterns are associated with pre-eclampsia, preterm birth, and IUGR.
  • These findings may elucidate the role of inflammation in the clinical manifestations of pregnancy complications.