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Regeneration of critical-sized mandibular defect using a 3D-printed hydroxyapatite-based scaffold: An exploratory
Po-Chun Chang1,2,3, Hui-Ting Luo1,2, Zhi-Jie Lin4
1Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Journal of Periodontology
|August 8, 2020
Summary
3D-printed hydroxyapatite scaffolds show promise for guided bone regeneration. These custom scaffolds promote new bone growth and tissue integration in rat models, demonstrating potential for clinical applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- 3D Printing Technology
Background:
- Three-dimensional (3D) printing enables custom tissue engineering scaffolds with intricate designs.
- Hydroxyapatite-based materials are explored for bone regeneration applications.
Purpose of the Study:
- Evaluate a 3D-printed hydroxyapatite-based scaffold for guided bone regeneration (GBR) in vivo.
- Assess the osteoregenerative potential of custom-designed scaffolds.
Main Methods:
- Fabricated 90% hydroxyapatite/10% poly(lactic-co-glycolic acid) scaffolds using microextrusion.
- Implanted scaffolds into rat mandibular defects and compared with controls.
- Analyzed gene expression on day 7 and micro-CT/histology on day 28.
Main Results:
- Scaffolds exhibited appropriate dimensions and pore sizes for defect filling.
- Upregulation of bone regeneration markers (collagen type I, VEGF, Cbfa1) by day 7.
- Significant de novo osteogenesis, scaffold-tissue integration, and bone formation by day 28.
Conclusions:
- 3D-printed hydroxyapatite scaffolds possess good dimensional stability.
- Demonstrated favorable osteoregenerative capability for guided bone regeneration.
