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Alpha Solanine: A Novel Natural Bioactive Molecule with Anticancer Effects in Multiple Human Malignancies
Sayyeda Hira Hassan1, Sameena Gul1, Hafiza Sadaf Zahra1
1Department of Zoology, University of the Punjab, Lahore, Punjab, Pakistan.
Abstract:
Cancer is one of the leading causes of death worldwide. Despite improvement in existing treatment modalities and addition of new anticancer drugs in the cancer clinic, cancer associated mortalities are continuously increasing. It is therefore, necessary to explore alternative treatment options to reduce the burden of cancer. In recent years, there is growing concern toward the use of natural products for treating cancer because of their ability to target multiple signaling molecules. α-solanine is a glycolalkaloid mainly present in potato tuber and Nightshade family plants. It possesses anti-pyretic, anti-diabetic, anti-allergic, anti-inflammatory and antibiotic activities. In recent years, α-solanine has been explored for its anticancer activity and showed promising results. Among all sources, potato peel contains adequate concentration of α-solanine. Every year, a large volume of potato peel is produced as a waste or sold at low cost. So α-solanine can be proved as an effective and cheap source for cancer therapy. The aim of this review is to summarize the recent data on anticancer activity of α-solanine and discuss it as a potential lead for cancer therapy.
Insights
Natural compound alpha-solanine (α-solanine), found in potato peels, shows promising anticancer activity. This review explores its potential as a cost-effective and natural alternative for cancer therapy.
Area of Science:
- Natural Product Chemistry
- Oncology
- Pharmacology
Background:
- Cancer remains a leading global cause of mortality despite advancements in treatment.
- There is a growing need for novel and effective cancer therapies.
- Natural products are increasingly investigated for their multi-targeting anticancer potential.
Purpose of the Study:
- To review recent findings on the anticancer activity of alpha-solanine (α-solanine).
- To evaluate alpha-solanine as a potential therapeutic lead for cancer treatment.
- To highlight potato peel as a viable and economical source of alpha-solanine.
Main Methods:
- Literature review of scientific studies on alpha-solanine.
- Analysis of research data on the anticancer properties of alpha-solanine.
- Assessment of alpha-solanine's presence and concentration in potato peels.
Main Results:
- Alpha-solanine (α-solanine) exhibits significant anticancer properties.
- Potato peel is identified as a rich and readily available source of alpha-solanine.
- The compound demonstrates potential for targeting multiple cancer signaling pathways.
Conclusions:
- Alpha-solanine (α-solanine) presents a promising natural compound for cancer therapy.
- Utilizing potato peel waste offers a cost-effective strategy for sourcing anticancer agents.
- Further research into alpha-solanine could lead to novel cancer treatment development.
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