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Updated: Dec 12, 2025

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Tranexamic acid in hip hemiarthroplasty.

Itay Ashkenazi1, Haggai Schermann1, Aviram Gold1

  • 1Division of Orthopedics, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Injury
|August 9, 2020
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Summary

Intraoperative tranexamic acid (TXA) significantly reduces 30-day mortality and blood loss in hip hemiarthroplasty patients. This study confirms TXA

Keywords:
Hip hemiarthroplastyPerioperative complicationsPostoperative blood lossTranexamic acid

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Area of Science:

  • Orthopedic Surgery
  • Trauma Surgery
  • Anesthesiology

Background:

  • Intraoperative tranexamic acid (TXA) is established for reducing blood transfusions in total joint arthroplasty.
  • Limited data exists on TXA's efficacy in hip hemiarthroplasty for trauma patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of intraoperative TXA in hip hemiarthroplasty for femoral neck fractures.

Main Methods:

  • A historical cohort study compared patients who received intraoperative TXA versus those who did not.
  • Outcomes assessed included blood loss, complications, readmissions, and mortality over a minimum one-year follow-up.

Main Results:

  • TXA use was associated with significantly reduced 30-day mortality (4.6% vs. 7.3%).
  • TXA significantly decreased perioperative blood loss (hemoglobin change: Δ-1.38 vs. Δ-1.76 gr/dL) and allogenic blood transfusions (17.5% vs. 44.4%).

Conclusions:

  • Intraoperative TXA effectively reduces 30-day mortality in hip hemiarthroplasty patients.
  • TXA use significantly lowers postoperative blood loss and the need for blood transfusions in this patient group.