Dosage Regimens: Partial Pharmacokinetic Parameters
Drug Administration and Therapy Phases: Overview
Drug Dosing: Geriatric Patients
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
Dosage Regimen: Individualization
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
You might also read
Articles linked to this work by shared authors, journal, and citation graph.
Updated: Dec 12, 2025

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
This study looked at how a centralized team of pharmacy technicians could handle medication refill requests in a large physician network. The team used standardized protocols built into an electronic medical record system to approve or deny refill requests for patients with chronic diseases. The refill process was moved from local clinics to a central team of certified pharmacy technicians (CPhTs). The CPhTs processed 81.7% of all refill requests, averaging 215 requests per day. Of the approved requests, 22.5% met the maximum refill quantity criteria, and 17.3% were given grace supplies until the patient’s scheduled office visit. The refill process included adjustments to refill quantity rules and communication protocols for denied refills. The researchers proposed that this model could reduce the workload on primary care staff and improve refill processing efficiency.
Area of Science:
Background:
Many primary care offices rely on office staff to process medication refill requests, often leading to inefficiencies and delays. Prior research has shown that medication refill workflows can vary widely across different clinics, and that this variability may contribute to inconsistencies in patient care. In some cases, refill requests are handled by medical assistants or providers, which can divert attention from more critical clinical tasks. However, no prior work had resolved how to centralize refill processing while maintaining safety and compliance. This gap motivated the exploration of alternative models, such as using certified pharmacy technicians (CPhTs) to handle refill requests. The study aimed to address the lack of standardized refill protocols across multiple clinic sites. It was already known that electronic medical records (EMRs) could be configured to support such workflows, but the specific application to refill approvals remained untested at scale. The need for a centralized refill process was driven by the desire to reduce the burden on primary care staff and improve refill turnaround time.
Purpose Of The Study:
The goal of this study was to evaluate how a centralized team of certified pharmacy technicians (CPhTs) could streamline medication refill approvals in a large physician network. The specific problem addressed was the inefficiency of having refill requests processed locally at each primary care (PC) office. The motivation was to reduce the workload on PC staff and ensure consistent refill processing across multiple clinic locations. The researchers proposed that shifting refill approvals to a centralized team could improve workflow efficiency and reduce errors. The study aimed to assess whether standardized refill protocols integrated into an EMR system could be effectively managed by CPhTs. The team also sought to measure the volume of refill requests handled by the CPhTs and the proportion of requests approved or denied. The researchers proposed that this model could serve as a scalable solution for large physician networks. The study focused on refill requests for chronic disease management, which often require frequent and consistent medication access.
Main Methods:
The study involved implementing a centralized refill approval process managed by certified pharmacy technicians (CPhTs) across nine primary care offices. Standardized refill protocols for 14 drug classes were integrated into the electronic medical record (EMR) system. Refill requests were shifted from local PC offices to a central CPhT team. The CPhTs followed predefined protocols to approve or deny refill requests based on patient data and scheduled visits. Pharmacists conducted random audits to ensure compliance with refill guidelines. Feedback was collected from providers, office staff, and patients to assess the process. Refill reports from January to March 2020 were analyzed to evaluate the volume of refill requests and approval rates. The study also tracked the number of refill requests that required further analysis by primary care staff.
Main Results:
The CPhT team processed 81.7% of all refill requests across the nine primary care offices. On average, each CPhT handled 215 refill requests per day. Of the approved requests, 22.5% met the protocol for maximum refill quantity and permitted refills. An additional 17.3% were granted grace supplies until the patient’s scheduled office visit. The refill process was supported by EMR protocols that included laboratory test value parameters and refill quantity rules. The CPhTs were also responsible for communicating with patients and pharmacies regarding denied refills. The study found that the majority of refill requests could be processed without direct involvement from primary care staff. The implementation included modifications to EMR documentation and adjustments to grace period refill quantities based on scheduled visit dates.
Conclusions:
The study showed that a centralized team of certified pharmacy technicians (CPhTs) could process the majority of medication refill requests in a large physician network. The CPhTs followed standardized protocols integrated into the electronic medical record (EMR) system to approve or deny refill requests. The implementation included adjustments to refill quantity rules and communication protocols for denied refills. The researchers proposed that this model could reduce the burden on primary care staff and improve refill processing efficiency. The study found that 81.7% of refill requests were processed by the CPhT team. The CPhTs handled an average of 215 refill requests per day. The study also showed that 22.5% of approved requests met the maximum refill quantity criteria. The researchers proposed that continuous evaluation and protocol adjustments could further improve workflow efficiency.
The CPhT team processed 81.7% of refill requests, averaging 215 requests per CPhT per day.
Standardized protocols for 14 drug classes were built into the EMR system.
To reduce the workload on PC staff and ensure consistent refill processing across multiple clinic locations.
CPhTs approved or denied refill requests based on EMR protocols and communicated with patients and pharmacies regarding denied refills.
22.5% of approved refill requests met the maximum refill quantity criteria.
The researchers proposed that this model could reduce the burden on primary care staff and improve refill processing efficiency.