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Updated: Dec 12, 2025

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
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Cannabinoids and the eye.

Michael T M Wang1, Helen V Danesh-Meyer1

  • 1Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

Survey of Ophthalmology
|August 9, 2020
PubMed
Summary
This summary is machine-generated.

Cannabis affects the eye in complex ways, showing potential for ocular surface injury but also risks like reduced corneal cells and neuroretinal dysfunction. Further research is needed for therapeutic applications.

Keywords:
cannabiscorneaeyelidglaucomaintraocular pressuremarijuanaoptic nerveretina

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Cannabis is a widely used psychotropic substance globally.
  • Increasing legalization necessitates understanding its physiological and pathological effects, particularly on the eye.

Purpose of the Study:

  • To provide an overview of current evidence on the ocular effects of cannabinoids.
  • To explore potential therapeutic applications and adverse effects of cannabinoids in ophthalmology.

Main Methods:

  • Review of existing scientific literature on cannabinoids and ocular health.
  • Analysis of studies investigating effects on intraocular pressure, ocular surface, and retinal function.
  • Examination of neuro-ophthalmic associations and potential treatment applications.

Main Results:

  • Cannabinoids, including delta-9-tetrahydrocannabinol and cannabidiol, have demonstrated ocular hypotensive and neuroprotective properties.
  • Potential therapeutic benefits for ocular surface injury and nystagmus were observed.
  • Adverse effects include decreased corneal endothelial density, neuroretinal dysfunction, and ocular motility deficits.

Conclusions:

  • While cannabinoids show promise for certain ophthalmic conditions like glaucoma and ocular surface injury, their use is limited by significant side effects.
  • Further research is crucial to elucidate the complex relationship between cannabinoids and ocular health, balancing potential benefits against risks.