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Updated: Dec 12, 2025
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Five new cassane diterpenes from the seeds and bark of Erythrophleum suaveolens
Ahmont Claude Landry Kablan1, Jacques Dibi Konan2, Gustav Komlaga3
1UFR des Sciences Biologiques, Université Peleforo Gon Coulibaly, BP 1328 Korhogo, Cote d'Ivoire; Laboratoire de Chimie Organique et de Substances Naturelles, UFR Sciences des Structures de la Matiere et Technologie, Universite Felix Houphouet-Boigny, 22 BP 582 Abidjan 22, Cote d'Ivoire; Équipe Chimie des Substances Naturelles, BioCIS, Université Paris-Saclay, CNRS, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.
Abstract:
Five new cassane-type diterpenoid heterosides, i. e. two cassane-type amides (1-2), two erythrophlamine-type amine esters (3-4) and a non‑nitrogenous erythrophlamine analogue (5) were isolated from the root barks (1-2) and the seeds (3-5) of Erythrophleum suaveolens. Their structures were unambiguously established by interpretation of their HRESIMS, 1D and 2D NMR data, and chemical degradation for sugar determination. Compounds 3-5 were evaluated for their cytotoxicity against a panel of three cell lines, revealing modest to strong activities.
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