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Updated: Dec 12, 2025

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Published on: July 3, 2015
Molecular hydrogen: A potential radioprotective agent.
Qiongge Hu1, Yunxiang Zhou2, Shijie Wu3
1Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hydrogen shows promise as a radioprotective agent due to its antioxidant properties. Further research into hydrogen
Area of Science:
- Biomedical science
- Radiology
- Antioxidant research
Background:
- Hydrogen exhibits selective antioxidant properties beneficial for various diseases.
- Ionizing radiation generates damaging hydroxyl radicals (OH) from water radiolysis.
- Hydrogen's ability to mitigate radiation damage presents therapeutic potential.
Purpose of the Study:
- To review the mechanisms behind hydrogen's radioprotective effects.
- To analyze effective hydrogen delivery methods for radio-protection.
- To evaluate in vitro, in vivo, and clinical evidence of hydrogen's radio-protective capabilities.
Main Methods:
- Literature review of existing studies on hydrogen and radio-protection.
- Analysis of proposed mechanisms of action for hydrogen's protective effects.
- Examination of data from in vitro, in vivo, and clinical trials.
Main Results:
- Hydrogen demonstrates significant potential as a radio-protective agent.
- Multiple mechanisms contribute to hydrogen's ability to mitigate radiation-induced damage.
- Evidence from various studies supports hydrogen's efficacy.
Conclusions:
- Hydrogen possesses notable radio-protective properties.
- Further research is warranted to fully explore hydrogen's clinical applications in radio-protection.
- Hydrogen represents a promising novel agent for radiation protection strategies.
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