EEG source estimation in a rare patient with cold-induced reflex epilepsy

Area of Science:

• Neurology
• Epileptology
• Clinical Neuroscience

Background:

• Temperature-related reflex epilepsy is predominantly associated with hot water immersion.
• Cold-induced reflex epilepsy is exceptionally rare, with limited documented cases.

Observation:

• A 70-year-old male presented with seizures consistently triggered by cold sensations.
• Clinical seizure induction and electroencephalogram (EEG) recordings were performed.
• Source estimation identified cortical regions involved in seizure generation.

Findings:

• Oxcarbazepine was the most effective antiepileptic drug among four tested.
• EEG data showed prominent beta rhythm in prefrontal lobes throughout ictal periods.
• Slow delta and theta rhythms originated in the occipital lobe and propagated to the right temporal lobe.

Implications:

• This case expands the understanding of cold-induced reflex epilepsy.
• Findings offer insights into the neural mechanisms and brain activity patterns of this rare epilepsy type.
• The study provides a reference for clinical management and pharmacological treatment strategies.