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Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms
Jaemin Lee1, Chanwoo Song1, Inhwan Noh1
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Korea.
Pharmaceutics
|August 9, 2020
Summary
This study demonstrates customizable drug release using hot-melt 3D extrusion (3D HME) to create modified-release dosage forms. Adjusting the 3D printed geometry allows for precise control over ibuprofen content and release profiles.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Drug Delivery Systems
Background:
- Traditional drug manufacturing faces limitations in customizability.
- 3D printing offers novel approaches for fabricating complex dosage forms.
- Hot-melt extrusion (HME) is a viable technique for incorporating active pharmaceutical ingredients (APIs) into polymer matrices.
Purpose of the Study:
- To fabricate modified-release solid dosage forms using hot-melt 3D extrusion (3D HME).
- To investigate the influence of geometrical properties on drug release.
- To achieve individualized API dosage and customizable release profiles.
Main Methods:
- Fabrication of solid dosage forms via simultaneous hot-melt 3D extrusion and deposition.
- Incorporation of ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG).
- Evaluation of physicochemical properties, dissolution rates, and floatable behavior.
Main Results:
- IBF content individualized by adjusting dosage form volume.
- Amorphous dispersion of IBF enhanced solubility and dissolution.
- Sustained release of IBF observed due to absence of disintegrant.
- Dissolution rate dependent on geometric properties and merging of geometries.
Conclusions:
- 3D HME provides a reproducible and accurate method for dosage form preparation.
- Geometrical customization of 3D printed dosage forms enables control over API dosage and release.
- This technology facilitates the development of personalized medicine with tailored release profiles.
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