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In-situ Electrospinning for Intestinal Hemostasis
Tongtong Zhou1, Yaozhong Wang2, Fengcai Lei3
1Collaborative Innovation Center for Nanomaterials & Devices, College of Physics, Qingdao University, Qingdao 266071, People's Republic of China.
International Journal of Nanomedicine
|August 9, 2020
Summary
In situ electrospinning effectively seals internal organ wounds, preventing fluid leakage in intestinal surgeries. This novel technique offers rapid hemostasis and reduces infection risk, paving the way for clinical applications.
Area of Science:
- Biomedical Engineering
- Surgical Innovation
- Materials Science
Background:
- Rapid hemostasis is crucial in surgery, particularly for internal organs.
- Sutures are often inadequate for organs like the intestines and bladder due to fluid leakage from pinholes.
- In situ electrospinning technology offers a promising solution for effective hemostasis.
Purpose of the Study:
- To evaluate the efficacy of hand-held electrospinning for sealing large intestine wounds.
- To compare hand-held electrospinning with traditional suturing methods.
- To assess the properties and safety of electrospun membranes for surgical applications.
Main Methods:
- Three types of 1 cm large intestine wounds were created: untreated, sutured, and treated with hand-held electrospinning.
- The hand-held electrospinning device was used with nitrile gloves to prevent infection.
- Nanofibrous membrane characteristics (diameter, pore size, elongation) were analyzed.
Main Results:
- Hand-held electrospinning effectively prevented fluid exudation from intestinal wounds.
- The resulting nanofibrous membrane had an average diameter of 0.5 μm with micrometer-sized pores.
- The membrane exhibited 90% elongation without breakage and allowed for safe, gloved application.
Conclusions:
- Hand-held electrospinning is a viable technique for preventing fluid leakage in intestinal surgery.
- The study provides a reference for future animal and clinical trials.
- Further investigation into the safety of this technology is recommended before widespread clinical use.
