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Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

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Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

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Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive Structural Color Changes.

Xiaoyan Sun¹, Lingzi Liu¹, Hui Zou¹

¹Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China.

International Journal of Nanomedicine

|August 9, 2020

Summary

This study presents novel multicolor microparticles for drug delivery. These intelligent particles offer controlled release via near-infrared light and visual feedback through color changes, improving drug delivery monitoring.

Keywords:

color change drug delivery graphene oxide microparticles photothermal effect

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Particle-based drug delivery systems (DDSs) are valuable but face challenges in stimuli-responsiveness and visual monitoring.
Existing DDSs often lack precise control over drug release and real-time feedback mechanisms.

Purpose of the Study:

To develop an intelligent, multicolor drug delivery system (DDS) with near-infrared (NIR) controlled release.
To enable macroscopic color changes for visual monitoring of drug release.

Main Methods:

Synthesized GO/pNIPAM/PEGDA composite hydrogel inverse opal microparticles using SCCBs as templates.
Incorporated dextran and calcium alginate hydrogel for drug encapsulation.
Utilized scanning electron microscopy, confocal laser scanning microscopy, and optical density measurements to characterize particles and monitor drug release.

Main Results:

Optimized concentrations of PEGDA (8% v/v) and GO (4 mg/mL) achieved a balance between volume shrinkage and structural color.
NIR irradiation induced microparticle shrinkage and drug release, evidenced by decreasing fluorescence intensity.
Structural color shifted from red to blue with increasing NIR exposure, allowing quantitative prediction of drug release.

Conclusions:

Developed multicolor microparticles demonstrate significant potential for advanced drug delivery applications.
The system offers vivid visual reporting, efficient photothermal drug release, and excellent stimuli-responsiveness.
This technology enhances the monitoring and control capabilities of drug delivery systems.